![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by Ted Pierik on June 15, 2001, at 14:29:38
Does anyone know about pregnancy and the use of Lamital.
My girlfriend is an epileptic (partial complex seizures in the temporal lob) taking lamital at 300 mg a day. She's had a bit of a rash lately, but it stopped by itself.
We want to take kids within a few years, but we cannot find sufficient info about the effect of lamital on the unborn child. Does someone have some info?
Thanks in advance,
Ted
Posted by Sulpicia on June 15, 2001, at 23:07:14
In reply to Lamital and pregnancy, posted by Ted Pierik on June 15, 2001, at 14:29:38
> Does anyone know about pregnancy and the use of Lamital.
>
> My girlfriend is an epileptic (partial complex seizures in the temporal lob) taking lamital at 300 mg a day. She's had a bit of a rash lately, but it stopped by itself.
>
> We want to take kids within a few years, but we cannot find sufficient info about the effect of lamital on the unborn child. Does someone have some info?
>
> Thanks in advance,
>
> Ted
Hi Ted--
I noticed you got some help with your question at MGH but
I must urge you in the strongest possible terms to have her
get ANY AND ALL rashes checked out immediately by an experienced
clinician. If your doc doesn't know what it is, insist on a
dermatologist -- as a last recourse if they can't diagnose it
they can biopsy it and rule out the dangerous lamictal rash.I'm not anti-lamictal: it saved my daughter's life and when\
she had a mild version of the *rash* I had to fight like a tiger
to get her back on it.
You absolutely must pay attention to any warning signs of lamictal
sensitivities -- are you aware of the other symptoms?It's a wonder drug for sure.
Best -- and for your future family too!
S.
Posted by SalArmy4me on June 15, 2001, at 23:44:37
In reply to Lamital and pregnancy, posted by Ted Pierik on June 15, 2001, at 14:29:38
Ohman, Inger. Vitols, Sigurd. Tomson, Torbjorn *. Lamotrigine in Pregnancy: Pharmacokinetics During Delivery, in the Neonate, and During Lactation. Epilepsia. 41(6):709-713, June 2000:
Conclusions: "Our data demonstrate a marked change in maternal LTG kinetics after delivery, possibly reflecting a normalization of an induced metabolism of LTG during pregnancy. LTG is excreted in considerable amounts in breast milk (the dose to the infant can be estimated to >=0.2-1 mg/kg/day 2-3 weeks postpartum), which in combination with a slow elimination in the infants, may result in LTG plasma concentrations comparable to what is reported during active LTG therapy. No adverse effects were observed in the infants, however."Tomson, Torbjorn. Lamotrigine in Pregnancy and Lactation: A Case Report. Epilepsia. 38(9):1039-1041, Sept 97:
"Plasma levels of LTG decreased as pregancy progressed. The ratio of dose to plasma concentration was 5.8 times higher at delivery and 3.6 times higher in late pregnancy as compared with 5 months postpartum, suggesting enhanced clearance of LTG during pregnancy. The concentration ratio of umbilical cord to mother's plasma was 1.2 indicating extensive passage of LTG over the placenta. The LTG plasma concentration in the newborn was still 48 h after birth similar to the plasma levels of the mother at delivery and in the umbilical cord. The ratio of milk to plasma concentration was 0.6 2 weeks after delivery and the plasma concentration in the breast-fed child was 25% of the mother's plasma levels. No adverse effects were observed in the newborn."
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.