Psycho-Babble Medication Thread 269850

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Zoloft affect dopamine at all?

Posted by superRitchie on October 15, 2003, at 21:49:07

Ive hurd many stories that zoloft affects dopamine, and many stories it hasnt. does zoloft really affect dopamine at high doses, or is that a bunch of bullcrap(ive hurd its more potent than even wellbutrin at high doses) I'm starting zoloft so, does any experinced people know how it affects you? Thanks Ritchie

Re: Zoloft affect dopamine at all?

Posted by Caleb462 on October 15, 2003, at 23:54:45

In reply to Zoloft affect dopamine at all?, posted by superRitchie on October 15, 2003, at 21:49:07

> Ive hurd many stories that zoloft affects dopamine, and many stories it hasnt. does zoloft really affect dopamine at high doses, or is that a bunch of bullcrap(ive hurd its more potent than even wellbutrin at high doses) I'm starting zoloft so, does any experinced people know how it affects you? Thanks Ritchie
>

Zoloft is a weak inhibitor of dopamine reuptake. In the usual dosing range (50-200 mg), I doubt there is any noticeable dopaminergic effect. However, if one were to push the dose higher (say 300-400 mg), I bet some signifigant DA reuptake inhibition would begin to take place. This is just a guess though.

Re: Zoloft affect dopamine at all?

Posted by sfloridamatt on October 21, 2003, at 11:27:10

In reply to Re: Zoloft affect dopamine at all?, posted by Caleb462 on October 15, 2003, at 23:54:45

> > Ive hurd many stories that zoloft affects dopamine, and many stories it hasnt. does zoloft really affect dopamine at high doses, or is that a bunch of bullcrap(ive hurd its more potent than even wellbutrin at high doses) I'm starting zoloft so, does any experinced people know how it affects you? Thanks Ritchie
> >
>
> Zoloft is a weak inhibitor of dopamine reuptake. In the usual dosing range (50-200 mg), I doubt there is any noticeable dopaminergic effect. However, if one were to push the dose higher (say 300-400 mg), I bet some signifigant DA reuptake inhibition would begin to take place. This is just a guess though.

zoloft is a very very weak inhibitor of dopamine. the sexual side effects associated with ssri's are supposedly due to the fact that they strongly inhibit the release of dopamine. taking l-tyrosine, precursor to dopamine and norepinephrine, helps the brain release more dopamine and in most people corrects the dopamine inbalance. adding a small amount of ritalin or dexedrine is sometimes added to an ssri because they release dopamine and also block the reuptake of dopamine
hope i helped some...
btw if u are gonna start taking l-tyrosine..doses range from 1500mg-2000mg daily taken in the morning on an EMPTY stomach.

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