Psycho-Babble Medication Thread 322277

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ssri question

Posted by dondon on March 8, 2004, at 22:42:20

Before ssri's came out, why didn't the drug companies
design their drugs to inhibit serotonin reuptake
along with blocking the 5-ht2 and 5-ht3 receptors?
They knew that nonselective stimulation of these receptors
caused the unwanted sexual side effects and that
stimulation of the 5-ht1 receptor was the mechanism
behind these drugs. I know that Prozac blocks
5-ht2c receptor. Also, does a reuptake inhibitor stimulate
the neurotransmitters receptors? Bupropion is a da reuptake
inhibitor(also stimulates d1,d2,d3 receptors). Noradrenaline
reuptake inhibitors would also stimulate central
noradrenergic receptors.

Re: ssri question

Posted by King Vultan on March 9, 2004, at 9:35:21

In reply to ssri question, posted by dondon on March 8, 2004, at 22:42:20

> Before ssri's came out, why didn't the drug companies
> design their drugs to inhibit serotonin reuptake
> along with blocking the 5-ht2 and 5-ht3 receptors?
> They knew that nonselective stimulation of these receptors
> caused the unwanted sexual side effects and that
> stimulation of the 5-ht1 receptor was the mechanism
> behind these drugs. I know that Prozac blocks
> 5-ht2c receptor. Also, does a reuptake inhibitor stimulate
> the neurotransmitters receptors? Bupropion is a da reuptake
> inhibitor(also stimulates d1,d2,d3 receptors). Noradrenaline
> reuptake inhibitors would also stimulate central
> noradrenergic receptors.

Actually, Stahl (Essential Psychopharmacology, 2nd Ed., 2000) shows Prozac as a 5HT2C agonist. In answer to your question, before they were introduced, I don't think the pharmaceutical companies realized the extent of the problems that SSRIs were going to cause. They were using imipramine and amitriptyline (which both blockade 5HT2A receptors, along with a bunch of other stuff) as examples of pharmacology to stay away from. In Kramer's Listening to Prozac book, I don't think there is even any mention of sexual side effects from Prozac. I think it took a few years for the psychiatric and pharmaceutical communities to become aware of the various drawbacks to SSRIs, just as the MAO inhibitors were not fully understood when they were first released, either.

As far as reuptake inhibitors stimulating receptors, all reuptake inhibitors are indirect agonists at the receptors associated with the neurotransmitter they are blocking reuptake of. Thus, bupropion is an indirect dopamine agonist.

Todd

Re: ssri question » King Vultan

Posted by Sad Panda on March 9, 2004, at 10:43:28

In reply to Re: ssri question, posted by King Vultan on March 9, 2004, at 9:35:21

>I don't think the pharmaceutical companies realized the extent of the problems that SSRIs were going to cause.
>
>

I don't think they cared either.

Cheers,
Panda.

Re: double double quotes » King Vultan

Posted by Dr. Bob on March 12, 2004, at 8:18:07

In reply to Re: ssri question, posted by King Vultan on March 9, 2004, at 9:35:21

> Stahl (Essential Psychopharmacology, 2nd Ed., 2000) shows Prozac as a 5HT2C agonist...

I'd just like to plug the double double quotes feature at this site:

http://www.dr-bob.org/babble/faq.html#amazon

The first time anyone refers to a book without using this option, I post this to try to make sure he or she at least knows about it. It's just an option, though, and doesn't *have* to be used. If people *choose* not to use it, I'd be interested why not, but I'd like that redirected to Psycho-Babble Administration:

http://www.dr-bob.org/babble/admin/20020918/msgs/7717.html

Thanks!

Bob

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