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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by ed_uk on September 10, 2005, at 14:20:30
BMC Med. 2005 Aug 22;3:14.
Suicide attempts in clinical trials with paroxetine randomised against placebo.Aursnes I, Tvete IF, Gaasemyr J, Natvig B.
Department of Pharmacotherapeutics, University of Oslo, Oslo, Norway. i.a.aursnes@medisin.uio.no
BACKGROUND: Inclusion of unpublished data on the effects of antidepressants on children has suggested unfavourable risk-benefit profiles for some of the drugs. Recent meta-analyses of studies on adults have indicated similar effects. We obtained unpublished data for paroxetine that have so far not been included in these analyses. METHODS: The documentation for drug registration contained 16 studies in which paroxetine had been randomised against placebo. We registered the number of suicides, suicide attempts and ideation. We corrected for duration of medication and placebo treatment and used a standard Bayesian statistical approach with varying priors. RESULTS: There were 7 suicide attempts in patients on the drug and 1 in a patient on placebo. We found that the probability of increased intensity of suicide attempts per year in adults taking paroxetine was 0.90 with a "pessimistic" prior, and somewhat less with two more neutral priors. CONCLUSION: Our findings support the results of recent meta-analyses. Patients and doctors should be warned that the increased suicidal activity observed in children and adolescents taking certain antidepressant drugs may also be present in adults.
Posted by spriggy on September 10, 2005, at 16:57:05
In reply to Paxil - suicide attempts - new study, posted by ed_uk on September 10, 2005, at 14:20:30
It's about time they start taking it seriously.
I wasn't on Paxil, but I was never suicidal in my whole life until being on Lexapro for 3 weeks.
I will never forget the "logic" in my thoughts about how I should just go and hang myself. It was so bizarre, as if I had no control over those thoughts (it was constant!).
If not for thinking of the consequances of killing myself on my husband and 2 son's, I likely would have done it.
That medicine made me feel like I was on the worst acid trip of my life-- so much so that ending my life seemed like the only way out of the nightmare.
It took me several months to feel like myself again.
This is the end of the thread.
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