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Dr. Bob is Robert Hsiung, MD,
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Posted by Jed_G on November 30, 2006, at 4:13:30
Good evening everyone,
I suffer from anxiety issues - helped greatly by the sedating anti depressants such as TCA's but not a great deal from SSRI's which make me feel all numbed out and out of touch with reality.
I find that I respond VERY quickly to AD's like imipramine and amitriptyline but they poop out just as quickly also, so I was thinking of rotating a couple of different TCA's to increase their long term effectiveness.
Would rotating different types of TCA's be a worthwhile exercise, or are they too chemically similar?
Has anyone had similar experiences with SSRI's vs. TCA's?
Cheerio,
John
Posted by Quintal on November 30, 2006, at 8:24:11
In reply to AD Rotation Question, posted by Jed_G on November 30, 2006, at 4:13:30
I'm no expert on TCAs but I've learned there can be quite big difference in terms of effects/side effects between them. I much prefer the side effect profile of TCAs over SSRIs myself and like you I respond much better to them.
I'm quite interested in trying trimipramine, because of its beneficial effects on REM sleep compared to most other antidepressants http://en.wikipedia.org/wiki/Trimipramine.
It also has some D2 antagonist action, giving it some possible antipsychotic effects.I'm not sure what you mean by rotating them. Do you mean continually switching between TCAs to maintain the effect?
Q
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