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Dr. Bob is Robert Hsiung, MD,
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Posted by PeterMartin on July 30, 2022, at 10:36:49
I have never done Memantine, but I ordered some last week to hopefully help reduce my tolerance to stimulants I take. I was really stoked about giving it a go until I stumbled on this study
It seems this 2016 study on PubMed claims Memantine had immunosuppressant properties. Not only that, but it suggests that the effects linger beyond the drug taking period and occurs even if the dose is kept low.
Study: https://pubmed.ncbi.nlm.nih.gov/27462773/
Abstract:
Memantine is approved for the treatment of advanced Alzheimer´s disease (AD) and reduces glutamate-mediated neuronal excitotoxicity by antagonism of N-methyl-D-aspartate receptors. In the pathophysiology of AD immune responses deviate and infectious side effects are observed during memantine therapy. However, the particular effects of memantine on human T lymphocytes are unresolved. Here, we provide evidence that memantine blocks Kv1.3 potassium channels, inhibits CD3-antibody- and alloantigen-induced proliferation and suppresses chemokine-induced migration of peripheral blood T cells of healthy donors. Concurrent with the in vitro data, CD4+ T cells from AD patients receiving therapeutic doses of memantine show a transient decline of Kv1.3 channel activity and a long-lasting reduced proliferative response to alloantigens in mixed lymphocyte reactions. Furthermore, memantine treatment provokes a profound depletion of peripheral blood memory CD45RO+ CD4+ T cells. Thus, standard doses of memantine profoundly reduce T cell responses in treated patients through blockade of Kv1.3 channels. This may normalize deviant immunopathology in AD and contribute to the beneficial effects of memantine, but may also account for the enhanced infection rate.
==Can someone verify I'm reading this correctly? And if so, I assume the risk would probably be not worth any potential benefit, yea?
Fortunately, I still haven't come down w/ COVID and I'm trying to keep it that way. If I do I'd like my immune system to not be less responsive.
My package will arrive today and I'm very conflicted now as to whether or not to try it for a few days (spaced out) this week at the lose dosage I always intended (5-10mg).
Thanks for any insight.
Posted by TriedEveryMedication on July 30, 2022, at 12:52:16
In reply to Memantine a risk to T-Cells? Help w/ study, posted by PeterMartin on July 30, 2022, at 10:36:49
The whole paper is found in the link below. As far as I can tell, they looked at 5 patients. That's not enough to draw any conclusions, really.
I would think if this was a major side-effect, it would show up in the clinical trials or as a symptom in the hundreds of thousands of people who take this drug. These end up as "black box" warnings on the drug monograph - there's no such warning for memantine
There's a lot of poor-quality papers published. Looks like the authors from this are from Otto von Guericke University Magdeburg, a university founded in 1993 and ranks #779 according to US News.
https://sci-hub.se/10.18632/oncotarget.10777
Posted by PeterMartin on July 30, 2022, at 14:00:46
In reply to Re: Memantine a risk to T-Cells? Help w/ study » PeterMartin, posted by TriedEveryMedication on July 30, 2022, at 12:52:16
haha nice on researching their background.
I really appreciate the reply. I might it give it a short trial.
Posted by linkadge on July 31, 2022, at 13:50:32
In reply to Re: Memantine a risk to T-Cells? Help w/ study, posted by PeterMartin on July 30, 2022, at 14:00:46
Yeah, it's probably not enough data to be sure.
I did a quick pubmed search and didn't exactly find a plethora of bad news immune wise. Some studies showed that it may have intrinsic antimicrobial effects or possible utility in COVID.
https://pubmed.ncbi.nlm.nih.gov/?term=memantine%20infection&page=2
When I read stuff like this, it concerns me, but clearly people aren't all getting sick from it. But, it is something worth keeping your eye on.
Linkadge
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