Psycho-Babble Alternative Thread 271590

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CFS study- small adrenal, high tyrosine in urine

Posted by loolot on October 21, 2003, at 17:02:38

Small adrenal glands in chronic fatigue syndrome: a preliminary computer tomography study.
Authors: Scott LV, Teh J, Reznek R, Martin A, Sohaib A, Dinan TG
Department of Psychiatry, Trinity College Dublin Medical School, St. James's, Hospital, Ireland.
Journal: Psychoneuroendocrinology 1999 Oct;24(7):759-68
NLM citations: PMID: 10451910, UI: 99381217

The right and left adrenal gland bodies were reduced by over 50% in the CFS subjects, a result with implications for CFS pathophysiology and possibly for therapies.

Dr Clifton Bligh, Royal Northshore Hospital CFS Unit, Department of Endocrinology, St Leonards, NSW 2065, Australia in conjunction with C P R Unit, Bioanalytical Research Group, Dept of Biological Sciences, University of Newcastle, Callaghan, NSW 2308

The most striking difference between CFS patients and controls was a reduction in urine asparginine (p<0.0001) and a reduction in urinary succinic acid (p<0.0003) in patients with CFS. Both of those correlated together (p<0.00001). Phenalanine were also significantly reduced. Also urinary tyrosine (p<0.04) and urinary 3-methyl histidine (p<0.03) were significantly increased in CFS. Increased tyrosine was associated with fatigue, muscle pain, lymph node pain and cognitive disturbance.
[CFS World Conference, Sydney, Australia, Feb 1999]

CHRONIC PAIN and PROTEIN TURNOVER in POLYSYMPTOMATIC PATIENTS Dr Neil McGregor, CPRU Unit University of Newcastle, Callaghan NSW 2308, in collaboration with Royal Northshore Hospital CFS Unit

Increased Rnase L is a good predictor of CFS fatigue

The increased urinary tyrosine : leucine ratio is found to be a good predictor of CFS pain/infectious symptoms. Tyrosine is a marker breakdown of protein, leucine is a marker for protein synthesis, therefore there is an increase in breakdown yet synthesis is impaired.
[CFS World Conference, Sydney, Australia, Feb 1999]

This syndrome, in fact, is emerging to be a purely physical illness, as shown by the 36 features it shares with Addison disease, an indisputable organic condition that no one would treat with CBT. All the physical symptoms and neuropsychological complaints that affect patients with CFS are found in addisonian subjects too, as a result of their shared adrenal insufficiency.
Baschetti, R. Investigations of hydrocortisone and fludrocortisone in the treatment of CFS. J Clin Endocrinol Metab.1999; 84-2263-2264

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